期刊

节点文献

海口地区37例中药注射剂严重不良反应报告分析

【作者】 容敏婷

【Author】 RONG Minting;Haikou Center for ADR Monitoring;

【机构】 海口市药品不良反应监测中心

【摘要】 目的分析海口地区中药注射剂的使用情况和严重不良反应(ADR)的特点,探究临床中药注射剂合理使用方法,为临床中药注射剂管理提供科学依据。方法检索2017年1月至2019年12月海口市药品不良反应监测中心接收的怀疑药品为中药注射剂的严重ADR报告,对相关信息进行统计分析。结果海口市近3年(2017—2019)中药注射剂严重ADR报告分布较为平均,37例报告中无10岁以下患者,患者年龄分布集中在55岁以上;37例报告中首次用药当天即发生严重药品ADR有31例;严重ADR构成比最高的药物品种主要是注射用血栓通(冻干)和注射用血塞通(冻干);中药注射剂所致严重ADR主要以过敏性休克、严重过敏样反应、高热、寒战为主;有29例是新的、严重ADR报告。结论通过主动收集中药注射剂近几年出现严重药品ADR的报告,重点关注在临床出现的新的、严重药品ADR和可能的影响因素,为临床合理用药提供依据,提高患者用药安全性。

【Abstract】 Objective To analyze the use of traditional Chinese medicine(TCM) injections and the characteristics of serious adverse drug reactions(ADR) in Haikou, explore the rational use of TCM injections in clinical, and provide scientific basis for the management of TCM injections. Methods From January 2017 to December 2019, the ADR reports of suspected TCM injections were collected by Haikou center for ADR monitoring, and the relevant information was statistically analyzed. Results The distribution of serious ADR of TCM injections in three years was relatively average.There were no patients under 10 years old in 37 cases, and the most concentrated age distribution of patients was over 55 years old. Among the 37 cases reported, 31 cases had serious ADR on the day of the first medication. Xueshuantong for injection(freeze-drying) and Xuesaitong for injection(freeze-drying) were the most common drugs with the highest proportion of serious adverse reactions. The major adverse reactions caused by TCM injections were anaphylactic shock, severe anaphylactic reaction, high fever and chills. 29 cases were new and serious ADR reports. Conclusion Through the active collection of reports of serious ADR of TCM injections in recent years, we focus on the new and serious ADR and possible influencing factors in clinical, so as to provide the basis for clinical rational drug use and improve the safety of drug use of patients.

【关键词】 中药注射剂严重ADR分析
  • 【DOI】10.16809/j.cnki.2096-3653.2020051506
  • 【分类号】R288
  • 【下载频次】161
节点文献中: